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. 2022 Nov 23;12:1027914. doi: 10.3389/fonc.2022.1027914

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Copyright © 2022 Priya, Jain, Akhtar, Saklani, Sakhuja, Agarwal, Polisetty, Sirdeshmukh, Kar and Gautam

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn diagram showing the differential level of 110 proteins in tissue (GBC) and in plasma/serum or plasma/serum-derived EVs (GBC or other cancers). The differential level of 16 proteins were already reported in tissue, plasma/serum and plasma/serum-derived EVs and are candidate proteins to be explored as circulatory markers for GBC. HP, Haptoglobin; LTF, lactotransferrin isoform 1; PKM, pyruvate kinase isoform X1; ANXA2, annexin A2; APOB, apolipoprotein B-100; APOE, apolipoprotein E isoform a; CLIC1, chloride intracellular channel protein 1; HMGB1, high mobility group protein B1 isoform X1; THBS1, thrombospondin-1; AHSG, alpha-2-HS-glycoprotein isoform 2; HBA1, hemoglobin subunit alpha; HSP90AA1, heat shock protein HSP 90-alpha isoform 1; ALB, serum albumin; TUBA4A, tubulin alpha-4A chain isoform 1; TUBB, tubulin beta chain isoform b; FLNA, Filamin-A isoform 2.