Table 2.

List of 16 proteins reported to be differentially abundant in GBC tissue as well as in plasma and plasma-derived EVs.

SNo.	Gene symbol	Protein name	Localization (Uniprot)	Molecular Functions (STRING database)
1	AHSG	alpha-2-HS-glycoprotein isoform 2	Secreted	Peptidase regulator activity, Endopeptidase inhibitor activity, Enzyme regulator activity
2	ALB	serum albumin	Extracellular region or secreted	Protein binding, Anion binding, Lipid binding, Identical protein binding
3	ANXA2	annexin A2 isoform 2	Extracellular region or Secreted	Cell adhesion molecule binding, Protein binding, Cadherin binding, Anion binding, Lipid binding
4	APOB	apolipoprotein B-100	Extracellular region or Secreted	Protein binding, Signaling receptor binding, Anion binding, Lipid binding
5	APOE	apolipoprotein E isoform a	Extracellular region or Secreted	Protein-containing complex binding, Protein binding, Signaling receptor binding, Anion binding, Lipid binding, Identical protein binding
6	CLIC1	chloride intracellular channel protein 1	Plasma membrane	Cell adhesion molecule binding, Protein binding, Cadherin binding, Binding
7	FLNA	Filamin-A isoform 2(Short name: FLN-A)	Extracellular region or secreted	Protein-containing complex binding, Protein binding, Cadherin binding, Signaling receptor binding, Identical protein binding
8	HBA1	hemoglobin subunit alpha	Extracellular region or secreted	Binding, Small molecule binding, Ion binding
9	HMGB1	high mobility group protein B1 isoform X1	Extracellular region or secreted	Cell adhesion molecule binding, Protein-containing complex binding, Integrin binding, Signaling receptor binding, Protein binding
10	HP	Haptoglobin isoform 1	Extracellular region or secreted	Protein binding, Binding
11	HSP90AA1	heat shock protein HSP 90-alpha isoform1	Plasma membrane	Protein-containing complex binding, Protein binding, Anion binding, Identical protein binding
12	LTF	lactotransferrin isoform 1 (Short name:Lactoferrin)	Extracellular region or secreted	Binding, Anion binding, Lipid binding
13	PKM	pyruvate kinase PKM isoform X1	Extracellular region or secreted	Cell adhesion molecule binding, Protein-containing complex binding, Protein binding, Cadherin binding, Anion binding, Identical protein binding
14	THBS1	thrombospondin-1	Extracellular region or Secreted	Cell adhesion molecule binding, Protein-containing complex binding, Integrin binding, Signaling receptor binding, Anion binding, Lipid binding, Identical protein binding
15	TUBA4A	tubulin alpha-4A chain isoform 1	Cytoplasm, Cytoskeleton	Protein binding, Binding, Anion binding
16	TUBB	tubulin beta chain isoform b	Cytoskeleton	Protein-containing complex binding, Protein binding, Signaling receptor binding, Anion binding