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. 2022 Nov 23;12:1043177. doi: 10.3389/fonc.2022.1043177

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Copyright © 2022 Jia, Li, Wang, Feng, Pan, Lin, Song, Yang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Upregulation and positive correlation of ZNF24 and SLC7A5 in KRAS mutant lung adenocarcinoma. (A, B) In the GSE72094 dataset and our RNA-seq, Heatmap of the top 10 high- and low-expression genes; ZNF24 and SLC7A5 are among these high-expression genes. (C, D) Weighted gene co-expression network analysis (WGCNA) of the GSE72094 dataset. (E) The genes co-expressed with SLC7A5 were screened by WGCNA on the sequencing samples, and the differentially expressed genes were screened in the online database. KRAS-mutant and KRAS wild-type cases were screened, and the genes closely related to SLC7A5 were screened for the intersection of the three sets of data. Take the intersection and draw VENN. (F) SLC7A5 positively correlates with ZNF24 expression in KRAS-mutant lung adenocarcinoma in GSE72094.