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. 2022 Nov 23;12:1043177. doi: 10.3389/fonc.2022.1043177

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Copyright © 2022 Jia, Li, Wang, Feng, Pan, Lin, Song, Yang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oncogenic RAS signaling regulates ZNF24 and SLC7A5 expression through MEK-ERK and PI3K-AKT pathways in KRAS mutant lung adenocarcinoma. (A, B) Gene set enrichment analysis (GSEA) diagram showing that SLC7A5 was enriched in the PI3K-AKT-mTOR signaling pathway. (C, D) qRT-PCR and Western blot results showed that the expression of SLC7A5 and ZNF24 was down-regulated after KRAS blockade. (E, F) The results of qRT-PCR and Western blot showed that the expression of SLC7A5 and ZNF24 was down-regulated after inhibiting MEK and PI3K. (G, H) The results of qRT-PCR and Western blot showed that the expression of SLC7A5 and ZNF24 was down-regulated after inhibiting ERK and AKT. The experiments were repeated 3 times. Abbreviations: shRNA, short hairpin RNA; NC, negative control. Data are shown as means ± SD. P values were calculated with two-tailed paired Student’s t-test, *p < 0.05, **p < 0.01, ***p < 0.001.