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. 2022 Nov 23;13:1062722. doi: 10.3389/fpls.2022.1062722

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Copyright © 2022 Tahir, Karagiannis and Tian

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The working model of HD2 family HDACs involved in drought stress response in Arabidopsis. (1: Han et al., 2016) HD2D was reported previously as a negative regulator of primary root length. Overexpression of HD2D caused a decrease in primary root length and increase in the number of secondary roots, and HD2D-OE plants showed enhanced tolerance to drought stress. (2: Li et al., 2017) HD2A and HD2B were shown to negatively coregulate the expression of GA2ox2 via histone acetylation modification, leading to decreased primary root growth in hd2a.hd2b double mutant. GA2ox genes are involved in the catabolism of bioactive gibberellins. (3) Our study showed that HD2A and HD2C coordinate to play role at both leaf and root levels by modulating the expression of ABI1 and ABI2, involved in ABA-mediated stomatal closure, and GA2ox genes. The knockout of both HD2A and HD2C showed abnormal stomatal functioning and decreased root growth in hd2a.hd2c double mutant, leading to decreased drought stress response. All arrow heads represent positive regulation, while all stop lines represent negative regulation associated with related pathways.