Table 1.
Clinical Characteristics of the NMS Cohort
| All patients (n=138) |
99 mTc-PYP uptake | P value | ||
|---|---|---|---|---|
| Negative (n=120) | Positive (n=18) | |||
| Age (years) | 73 [63–82] | 71 [63–80] | 84 [77–87] | <0.001 |
| Male sex | 89 (65) | 75 (63) | 14 (78) | 0.207 |
| NYHA functional class | 0.099 | |||
| I | 36 (26) | 35 (29) | 1 (5.6) | |
| II | 86 (62) | 73 (61) | 13 (72) | |
| III | 15 (11) | 11 (9.2) | 4 (22) | |
| IV | 1 (0.7) | 1 (0.8) | 0 | |
| Hypertension | 98 (71) | 85 (71) | 13 (72) | 0.904 |
| Atrial fibrillation | 61 (44) | 49 (41) | 12 (67) | 0.040 |
| Spinal canal stenosis | 20 (15) | 8 (6.7) | 12 (67) | <0.001 |
| Carpal tunnel syndrome | 8 (5.8) | 3 (2.5) | 5 (28) | 0.001 |
| Pacemaker implantation | 20 (15) | 17 (14) | 3 (17) | 0.726 |
| Laboratory examinations | ||||
| Albumin (g/dL) | 3.8 [3.4–4.1] | 3.8 [3.4–4.1] | 4.0 [3.6–4.3] | 0.132 |
| Creatinine (mg/dL) | 1.1 [0.8–1.5] | 1.0 [0.8–1.6] | 1.1 [1.0–1.5] | 0.695 |
| hs-cTnT (ng/mL) | 0.035 [0.021–0.054] | 0.031 [0.020–0.052] | 0.053 [0.038–0.077] | 0.001 |
| NT-proBNP (pg/mL) | 1,325 [395–3,524] | 1,193 [291–3,725] | 2,254 [1,243–3,054] | 0.100 |
| ECG parameters | ||||
| Heart rate (beats/min) | 71 [61–83] | 71 [62–83] | 60 [55–77] | 0.025 |
| Prolonged PR interval | 39 (28) | 30 (25) | 9 (50) | 0.028 |
| Wide QRS | 41 (30) | 32 (27) | 9 (50) | 0.043 |
| RBBB | 22 (16) | 19 (16) | 3 (17) | 1.000 |
| LBBB | 13 (9.4) | 8 (6.7) | 5 (28) | 0.014 |
| Low voltage | 14 (10) | 10 (8.3) | 4 (22) | 0.088 |
| Poor R progression | 27 (20) | 20 (17) | 7 (39) | 0.050 |
| Echocardiographic parameters | ||||
| LVEF (%) | 56 [44–69] | 56 [43–69] | 54 [44–68] | 0.892 |
| LVEDD (mm) | 48±8 | 48±8 | 43±8 | 0.014 |
| LVESD (mm) | 32 [27–41] | 33 [27–42] | 29 [26–37] | 0.227 |
| IVS thickness (mm) | 12 [9–13] | 12 [9–13] | 13 [12–14] | 0.009 |
| PWT (mm) | 11 [9–13] | 11 [9–12] | 14 [12–17] | <0.001 |
| Left atrium diameter (mm) | 42±8 | 41±8 | 43±7 | 0.389 |
| E/A ratio | 0.9 [0.6–1.4] | 0.9 [0.6–1.3] | 1.6 [1.0–2.9] | 0.003 |
| E-wave deceleration time (ms) | 194 [154–254] | 193 [154–253] | 204 [148–313] | 0.354 |
| E/e’ ratio | 16 [12–23] | 15 [11–22] | 22 [15–31] | 0.016 |
| Aortic stenosis | 18 (13) | 16 (13) | 2 (11) | 1.000 |
| Pericardial effusion | 32 (23) | 27 (23) | 5 (28) | 0.566 |
Categorical data are presented as n (%). Continuous data are presented as the median [interquartile range] or as the mean±SD, as appropriate. ECG, electrocardiogram; hs-cTnT, high-sensitivity cardiac troponin T; IVS, interventricular septum; LBBB, left bundle branch block; LVEDD, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic diameter; NMS, Nippon Medical School; NT-proBNP, N-terminal pro B-type natriuretic peptide; NYHA, New York Heart Association; PWT, posterior wall thickness; PYP, pyrophosphate; RBBB, right bundle branch block.