Table 2.
Clinical Characteristics of 99 mTc-PYP Scintigraphy Positive Patients in Each Cohort
| NMS cohort (Tokyo) |
Fukuoka cohort10,11 | Kochi cohort9 | Kumamoto cohort8 | |
|---|---|---|---|---|
|
% Positive uptake on 99 mTc-PYP scintigraphy |
13 (18/138) | 18 (18/98) | 47 (70/150) | 39 (70/181) |
| Age (years) | 84 [77–87] | 82±12 | 81 [77–85] | 80±6 |
| Male sex | 14 (78) | 12 (67) | 61 (87) | 58 (83) |
| Hypertension | 13 (72) | NA | 37 (53) | 36 (51) |
| Atrial fibrillation | 12 (67) | 9 (50) | 38 (54) | 24 (34) |
| Spinal canal stenosis | 12 (67) | NA | 16 (23) | NA |
| Carpal tunnel syndrome | 5 (28) | NA | 32 (46) | NA |
| Laboratory examinations | ||||
| hs-cTnT (ng/mL) | 0.053 [0.038–0.077] | NA | 0.065 [0.055–0.095] | 0.049 [0.035–0.071] |
| BNP (pg/mL) | NA | NA | 304 [216–525] | 245 [133–415] |
| NT-proBNP (pg/mL) | 2,254 [1,243–3,054] | 4,658 [126–31,096] | NA | NA |
| ECG parameters | ||||
| Wide QRS | 9 (50) | NA | 30 (43) | 31 (44) |
| Prolonged PR interval | 9 (50) | NA | 15 (21) | 28 (40) |
| Low voltage | 4 (22) | 1 (5.6) | 29 (48) | 15 (21) |
| Poor R progression | 7 (39) | 9 (50) | 25 (36) | 15 (21) |
| Echocardiographic parameters | ||||
| LVEF (%) | 54 [44–68] | 54±13 | 52 [43–59] | 53±10 |
| LVEDD (mm) | 43±8 | 46±9 | 46 [42–50] | 43±6 |
| LVESD (mm) | 29 [26–37] | 33±9 | 34 [30–38] | 31±7 |
| IVS thickness (mm) | 13 [12–14] | 13±4 | 14 [13–15] | 15±2 |
| PWT (mm) | 14 [12–17] | 13±3 | 13 [12–15] | 15±3 |
Categorical data are presented as n (%). Continuous data are presented as the median [interquartile range] or as the mean±SD, as appropriate. Abbrevitions as in Table 1.