Table 3.
Factors Associated With Positive Uptake on 99 mTc-PYP Scintigraphy in the NMS and Kumamoto8 Cohorts
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Positive LR | Negative LR | AUC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NMS | Kumamoto | NMS | Kumamoto | NMS | Kumamoto | NMS | Kumamoto | NMS | Kumamoto | NMS | Kumamoto | NMS | Kumamoto | |
|
Kumamoto criteria score ≥2 |
67 | 73 | 78 | 84 | 31 | 74 | 94 | 83 | 3.0 | 4.6 | 0.4 | 0.3 | 0.808 | 0.822 |
| hs-cTnT (≥0.0308ng/mL) |
89 | 80 | 49 | 59 | 21 | NA | 97 | NA | 1.8 | 2.0 | 0.2 | 0.3 | 0.739 | 0.730 |
| Wide QRS (≥120 ms) |
50 | 44 | 73 | 80 | 22 | 59 | 91 | 70 | 1.8 | 2.2 | 0.7 | 0.7 | NA | NA |
| PWT (≥13.6 mm) | 56 | 70 | 89 | 87 | 44 | NA | 93 | NA | 5.1 | 5.4 | 0.5 | 0.3 | 0.814 | 0.859 |
| Other factors | ||||||||||||||
| SCS | 67 | NA | 93 | NA | 60 | NA | 95 | NA | 9.6 | NA | 0.4 | NA | NA | NA |
| CTS | 28 | NA | 98 | NA | 63 | NA | 90 | NA | 14.0 | NA | 0.7 | NA | NA | NA |
| SCS and/or CTS | 78 | NA | 92 | NA | 58 | NA | 97 | NA | 9.8 | NA | 0.2 | NA | NA | NA |
AUC, area under the curve; CTS, carpal tunnel syndrome; hs-cTnT, high-sensitivity cardiac troponin T; LR, likelihood ratio; NMS, Nippon Medical School; NPV, negative predictive value; PPV, positive predictive value; PWT, posterior wall thickness; PYP, pyrophosphate; SCS, spinal canal stenosis.