Table 4.
Changes in the Absolute Lymphocyte Count and MMP-2 Expression in Bone Marrow Micro-Metastasis with Time, Comparing Men with and without Biochemical Failure
| Time of sampling | ALC decreasing (N=37) | ALC stable (N=43) | p value |
|---|---|---|---|
| One month post surgery | |||
| Median ALC (IQR) | 2.00 (1.35-2.47 | 2.4 (2.26-2.70) | p=0.99a |
| MMP-2 | |||
| > 10% | 2 (5%) | 0 | |
| 1-10% | 4 (11%) | 0 | p=0.54b |
| 0% | 31 (84%) | 43 (100%) | |
| MMP-2 score | 0.37 ± 0.24 | 0.36 ± 0.21 | p=0.97a |
| 18 months prior to BF/censure | |||
| median ALC (IQR) | 1.80 (1.20-2.12) | 2.50 (2.30-2.60) | p<0.0001a |
| MMP-2 | |||
| >10% | 5 ((14%) | ||
| 1-10% | 8 (22%) | ||
| 0% | 24 (64%) | ||
| MMP-2 score | 0.98 ± 0.47 | ||
| 12 months prior to BF/censure | |||
| median ALC (IQR) | 1.50 (1.10-2.12) | 2.50 (2.40-2.60) | p<0.0001a |
| MMP-2 | |||
| > 10% | 11 ((30%) | ||
| 1-10% | 15 (40%) | ||
| 0% | 11 (30%) | ||
| MMP-2 score | 1.37 ± 0.85 | ||
| 6 months prior to BF/censure | |||
| median ALC (IQR) | 1.30 (1.00-1.50) | 2.50 (2.20-2.70) | p<0.0001a |
| MMP-2 | |||
| > 10% | 12 (32%) | ||
| 1-10% | 20 ((54%) | ||
| 0% | 5 (14%) | ||
| MMP-2 score | 1.83 ± 0.74 | ||
| BF/censure | |||
| median ALC (IQR) | 1.10 (0.80-1.30) | 2.50 (2.20-2.80) | p<0.0001a |
| MMP-2 | |||
| >10% | 12 (32%) | 0 (0%) | |
| 1-10% | 20 (54%) | 1 (2%) | |
| 0% | 5 (14%) | 42 (98%) | p<0.001b |
| MMP-2 score | 1.97 ± 1.05 | 0.38 ± 0.15 | p<0.001a |
ALC, absolute lymphocyte count; IQR, interquartile range; BF, biochemical failure; a, Mann Whitney test; b, Fisher´s exact test