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Cytokine Production by CD8 + T-cells after PD-1 and TIGIT Blockade. CD8+ T-cells separated from CLL patients were treated with anti PD-1 and anti TIGIT blocking antibodies and then co-cultured with malignant B-cells as target cells. Cells were then stimulated with PMA/ionomycin and then their supernatants were collected to evaluate cytokine production levels. TNF-α (A) and IFN-γ (B) concentrations were measured using ELISA
