Table 1.
Data from Studies Regarding the Association of Pretherapeutic ADC Values with OS of PCNSL Patients
| Study (Year) | Regio | Study Design | Patients | Methods of ADC used | ADC Cut-off values used (10-6 mm2/s) | OS (Low ADC group vs high ADC group) |
Hazard Ratio (HR) | 95%CI | p-value |
|---|---|---|---|---|---|---|---|---|---|
| Barajas et al. (2010) | United States | Cohort | 18 | ADC25% | 692 | Mean OS 15.8 months vs 30.9 months; p = <0.01 | 0.12 (multivariate analysis) | 0.02 - 0.71 | 0.02 |
| ADCmin | 384 | 0.01 (multivariate analysis) | 0.00 – 0.33 | 0.01 | |||||
| Valles et al. (2013) | United States | Cohort | 25 | ADCmin | 384 | Mean OS 12.1 months vs 20.1 months; p = 0.05 | 0.29 (multivariate analysis) | 0.102 - 0.824 | 0.02 |
| Dong Wo Baek et al. (2020) | South Korea | Cohort | 52 | Reference to Barajas et al.10 | Reference to Barajas et al.10 |
OS at 3 year was shorter, (56.0±3.7% vs 76.5%±8.6%); p = 0.05 |
0.392 (multivariate analysis) | 0.155 - 0.854 | 0.12 |