Table 2.
The MHC II Epitope Prediction, HLA Coverage, and Percent Conservancy of Top L1 and L2 HPV 52 Epitopes
| No | Sequences | Allele | HPV type conservansy | persen conservansy | |||||
|---|---|---|---|---|---|---|---|---|---|
| L1 HPV52 | |||||||||
| 1 | YRFVTSTAITCQKNT | HLA-DRB1*07:01, HLA-DPA1*02:01, HLA-DPB1*14:01, HLA-DRB3*02:02, HLA-DRB1*04:01, HLA-DQA1*01:02, HLA-DQB1*06:02, HLA-DRB1*04:05, HLA-DRB5*01:01, HLA-DRB1*01:01 | HPV70 (53.33%), HPV39,51,66,68 (60%), HPV34,35,56 (66.67%), HPV18,45,59 (73.33%), HPV16,31,33,58 (80%), HPV52 (100%) | 100.00% (16/16) | |||||
| 2 | VQILFYILVIFYYVA | HLA-DQA1*05:01, HLA-DQB1*02:01, HLA-DQA1*01:01, HLA-DQB1*05:01, HLA-DRB1*15:01, HLA-DPA1*02:01, HLA-DPB1*01:01, HLA-DPA1*03:01, HLA-DPB1*04:02, HLA-DRB1*04:05, HLA-DPA1*01:03, HLA-DPB1*02:01, HLA-DPA1*02:01, HLA-DPB1*05:01, HLA-DRB1*11:01, HLA-DRB3*01:01, HLA-DRB4*01:01 | HPV52 (100%) | 6.25% (1/16) | |||||
| 3 | MVQILFYILVIFYYV | HLA-DQA1*05:01, HLA-DQB1*02:01, HLA-DQA1*01:01, HLA-DQB1*05:01, HLA-DRB1*15:01, HLA-DPA1*02:01, HLA-DPB1*01:01, HLA-DPA1*01:03, HLA-DPB1*02:01, HLA-DPA1*03:01, HLA-DPB1*04:02, HLA-DRB1*04:05, HLA-DRB3*01:01, HLA-DRB1*11:01, HLA-DRB4*01:01 | HPV52 (100%) | 6.25% (1/16) | |||||
| 4 | EPYGDSLFFFLRREQ | HLA-DPA1*01:03, HLA-DPB1*04:01, HLA-DPA1*02:01, HLA-DPB1*05:01, HLA-DPA1*01:03, HLA-DPB1*02:01, HLA-DPA1*02:01, HLA-DPB1*01:01, HLA-DQA1*01:01, HLA-DQB1*05:01, HLA-DRB1*11:01 | HPV34,51,56,66,70 (66.67%), HPV39,59,68 (73.33%), HPV18,45 (80%), HPV31,35 (86.67%), HPV16 (93.33%), HPV52,33,58 (100%) | 100.00% (16/16) | |||||
| 5 | GRKFLLQAGLQARPK | HLA-DPA1*02:01, HLA-DPB1*14:01, HLA-DRB1*01:01, HLA-DRB3*02:02, HLA-DRB4*01:01, HLA-DRB1*11:01, HLA-DPA1*01:03, HLA-DPB1*04:01, HLA-DRB1*04:01 | HPV56 (53.33%), HPV59 (60%), HPV18, 39, 51, 70 (66.67%), HPV34, 45, 58, 68 (73.33%), HPV16, 31, 33, 35 (86.67%), HPV52 (100%) | 93.75% (15/16) | |||||
| 6 | ILFYILVIFYYVAGV | HLA-DRB1*15:01, HLA-DQA1*01:01, HLA-DQB1*05:01,HLA-DQA1*05:01, HLA-DQB1*02:01, HLA-DPA1*02:01, HLA-DPB1*01:01, HLA-DPA1*03:01, HLA-DPB1*04:02, HLA-DRB1*04:05, HLA-DPA1*01:03, HLA-DPB1*02:01, HLA-DPA1*02:01, HLA-DPB1*05:01, HLA-DRB1*11:01, HLA-DRB3*01:01, HLA-DRB1*13:02 | HPV52 (100%) | 6.25% (1/16) | |||||
| 7 | PYGDSLFFFLRREQM | HLA-DPA1*01:03, HLA-DPB1*02:01, HLA-DPA1*02:01, HLA-DPB1*05:01, HLA-DPA1*01:03, HLA-DPB1*04:01,HLA-DPA1*02:01, HLA-DPB1*01:01,HLA-DQA1*01:01, HLA-DQB1*05:01, HLA-DRB1*11:01 | HPV51,56,66,70 (66.67%), HPV34,39,59,68 (73.33%), HPV18,45 (80%), HPV31,35 (86.67%), HPV16 (93.33%), HPV52,33,58 (100%) | 100.00% (16/16) | |||||
| 8 | RKFLLQAGLQARPKL | HLA-DPA1*02:01, HLA-DPB1*14:01, HLA-DRB1*01:01, HLA-DRB3*02:02, HLA-DRB4*01:01, HLA-DRB1*11:01, HLA-DPA1*01:03, HLA-DPB1*04:01, HLA-DRB1*04:01, HLA-DRB5*01:01 | HPV59 (53, 33%), HPV18, 39, 51, 70 (60%), HPV45, 68 (66.67%), HPV34, 58 (73.33%), HPV16, 31, 35 (80%), HPV86 (86.67%), HPV52 (100%) | 87.50% (14/16) | |||||
| 9 | FYILVIFYYVAGVNV | HLA-DRB1*01:01, HLA-DRB1*15:01, HLA-DQA1*01:01, HLA-DQB1*05:01, HLA-DPA1*01:03, HLA-DPB1*02:01, HLA-DPA1*02:01, HLA-DPB1*01:01, HLA-DRB1*13:02, HLA-DPA1*03:01, HLA-DPB1*04:02, HLA-DRB1*07:01, HLA-DRB1*08:02, HLA-DRB1*04:05, HLA-DRB1*11:01 | HPV56 (53.33%), HPV52 (100%) | 12.50% (2/16) | |||||
| 10 | GKKVLVPKVSGLQYR | HLA-DRB1*08:02, HLA-DRB1*12:01 | HPV56, 59 (53.33%), HPV18, 39,66,68,70 (60%), HPV45 (66.67%), HPV34, 35 (73.33%), HPV16, 31 (80%), HPV33 (86.67%), HPV58 (93.33%), HPV32 (100%) | 93.75% (15/16) | |||||
| 9 | SLGVFFGGLGIGTGA | HLA-DQA1*05:01/DQB1*03:01 | HPV35,51,56,66 (73.33%), HPV18,31,34,39,45,59,68,70 (80%), HPV16 (86.67%), PV33,58 (93.33%), HPV52 (100%) | 100.00% (16/16) | |||||
| 10 | GSLGVFFGGLGIGTG | HLA-DQA1*05:01/DQB1*03:01 | HPV51 (73.33%), HPV18,35,39,45,56,59,66,68,70 (80%), HPV31,34 (86.67%), HPV16 (93%), HPV52,33,58 (100%) | 100.00% (16/16) | |||||
| L2 HPV52 | |||||||||
| 1 | ADQLLKYGSLGVFFG | HLA-DRB1*15:01, HLA-DRB1*12:01, HLA-DRB1*13:02, HLA-DRB1*04:05, HLA-DRB1*07:01 | HPV18, 39,45,56,59,66,68,70 (53.33%), HPV16 (73.33%), HPV31, 35 (80%), HPV34, 58 (86.67%), HPV33 (93.33%), HPV52 (100%) | 93.75% (15/16) | |||||
| 2 | TIADQLLKYGSLGVF | HLA-DRB1*15:01, HLA-DRB1*12:01 | HPV18, 39, 45,59,68,70 (53.33%), HPV16, 35 (73.33%), HPV31, 34 (80%), HPV58 (86.67%), HPV33 (93.33%), HPV52 (100%) | 81.25% (13/16) | |||||
| 3 | TTIADQLLKYGSLGV | HLA-DRB1*15:01, HLA-DRB1*12:01 | HPV18, 39, 45,59,68,70 (53.33%), HPV16, 35(66.67%), HPV34 (73.33%), HPV31 (80%), HPV33, 58 (86.67%), HPV52 (100%) | 81.25% (13/16) | |||||
| 4 | FFGGLGIGTGAGSGG | HLA-DQA1*05:01/DQB1*03:01 | HPV18,31,34,35,39,59,68,70 (80%), HPV16,45,51,56,58,66 (88.67%), HPV33 (93.33%), HPV52 (100%) | 100.00% (16/16) | |||||
| 5 | GVFFGGLGIGTGAGS | HLA-DQA1*05:01/DQB1*03:01 | HPV18,35,39,56,59,66,68,70 (73.33%), HPV31,34,45,51 (80%), HPV16,58 (86.67%), HPV33 (93.33%), HPV52 (100%) | 100.00% (16/16) | |||||
| 6 | GAGSGGRAGYVPLST | HLA-DQA1*05:01/DQB1*03:01 | HPV18,39,59,68,70 (60%), HPV16,51,58 (66.67%), HPV33,34,35,45 (73.33%), HPV31,56,66 (80%), HPV52 (100%) | 100.00% (16/16) | |||||
| 7 | VFFGGLGIGTGAGSG | HLA-DQA1*05:01/DQB1*03:01 | HPV18,39,59,68,70 (73.33%), HPV31,34,35,45,51,56,66 (80%), HPV16,58 (86.67%), HPV33 (93.33%), HPV52 (100%) | 100.00% (16/16) | |||||
| 8 | LGVFFGGLGIGTGAG | HLA-DQA1*05:01/DQB1*03:01 | HPV35,56,66 (73.33%), HPV18,31,34,39,45,51,59,68,70 (80%), HPV16 (86.67%), HPV33,58 (93.33%), HPV52 (100%) | 100.00% (16/16) | |||||
| 9 | SLGVFFGGLGIGTGA | HLA-DQA1*05:01/DQB1*03:01 | HPV35,51,56,66 (73.33%), HPV18,31,34,39,45,59,68,70 (80%), HPV16 (86.67%), PV33,58 (93.33%), HPV52 (100%) | 100.00% (16/16) | |||||
| 10 | GSLGVFFGGLGIGTG | HLA-DQA1*05:01/DQB1*03:01 | HPV51 (73.33%), HPV18,35,39,45,56,59,66,68,70 (80%), HPV31,34 (86.67%), HPV16 (93%), HPV52,33,58 (100%) | 100.00% (16/16) | |||||