Table 3.
Living Status and Overall Survival of Locally Advanced Cervical Patients who had Failure after Primary Treatment According to Characteristic Features of the Patients and Type of Salvage Therapy
| Characteristic features | Status, n (%) | OS (month; 95% CI) |
Unadjusted HR (95% CI) |
Adjusted HR (95% CI) |
|
|---|---|---|---|---|---|
| Alive | Dead | ||||
| Age | 0.61 (0.29-1.25) | 0.62 (0.26-1.46) | |||
| ≤ 40 years (n=14) | 5 (35.7) | 9 (64.3) | 17.1 (4.4-69.6) | ||
| > 40 years (n=71) | 26 (36.6) | 45 (63.4) | 29.0 (4.8-67.9) | ||
| Stage | 2.06 (1.19-3.56) | 2.16 (1.16-4.02) | |||
| II (n=45) | 23 (51.1) | 22 (48.9) | 31.5 (4.4-69.6) | ||
| III-IV (n=40) | 8 (20.0) | 32 (80.0) | 25.3 (4.8-63.7) | ||
| Performance status | 1.43 (0.90-2.27) | 2.18 (1.15-4.12) | |||
| 0-1 (n=80) | 31 (38.8) | 49 (61.2) | 27.3 (4.4-69.6) | ||
| 2-4 (n=5) | - | 5 (100) | 27.3 (6.9-44.7) | ||
| Treatment-free interval | 0.12 (0.06-0.24) | 0.12 (0.06-0.24) | |||
| ≤ 6 months (n=25) | 2 (8.0) | 23 (92.0) | 14.1 (4.4-36.4) | ||
| > 6 months (n=41) | 21 (51.2) | 20 (48.8) | 38.7 (9.5-69.6) | ||
| Type of failures | 1.05 (0.73-1.52) | 1.01 (0.64-1.59) | |||
| Local (n=45) | 15 (33.3) | 30 (64.7) | 27.7 (20.6-34.9) | ||
| Systemic (n=26) | 13 (50) | 13 (50) | 35.9 (32.6-50.4) | ||
| Local and Systemic (n=14) | 3 (21.4) | 11 (78.6) | 16.8 (14.2.0-40.2) | ||
| Primary treatment | 1.24 (0.72-2.13) | 1.18 (0.61-2.26) | |||
| CCRT (n=39) | 16 (41.0) | 23 (59.0) | 27.9 (4.8-64.4) | ||
| CCRT+ACT (n=46) | 15 (32.6) | 31 (77.4) | 24.6 (4.4-69.6) | ||
| Salvage therapy | 1.036 (0.87-1.23) | 1.17 (0.84-1.63) | |||
| Radiation therapy (n=8) | 2 (25.0) | 6 (75) | 31.7 (4.4-59.6) | ||
| Surgery (n=2) | 2 (100) | - | 61.2 (52.7-69.6) | ||
| Chemotherapy (n=29) | 9 (31.0) | 20 (69.0) | 25.2 (6.3-64) | ||
| Combine treatment (n=18) | 10 (55.6) | 8 (44.4) | 37.0 (9.5-64.4) | ||
| Supportive care (n=9) | - | 9 (100) | 7.9 (4.8-16.2) | ||
Note: Performance status referred to performance status of the patients at the time of event; Treatment-free interval referred to duration from the last date of primary treatment to the date of event