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. 2022 Nov 23;16:1066528. doi: 10.3389/fnins.2022.1066528

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Copyright © 2022 Zeng, Li, Jiang, Lan, Chen, Chen, Li, Hui, Zhang, Hu and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolomic results for group sham vs. the acute-phase spinal cord injury in both positive ion mode and negative ion mode. (A,B) Volcano plot in both positive ion mode and negative ion mode. Each dot represents a metabolite, with significantly upregulated metabolites are indicated in red, significantly down-regulated metabolites are indicated in blue, and non-significantly different metabolites are in gray based on variable importance in the projection > 1 and P < 0.05. (C,D) Heatmap of hierarchical clustering analysis in both positive ion mode and negative ion mode. The horizontal axis represents different experimental groups, the vertical axis represents the differential metabolites compared in that group, the color blocks at different positions represent the relative expression of metabolites in the corresponding position, red color indicates that the substance is highly expressed in the group, blue color indicates that the substance is lowly expressed in the group. (E,F) Pathway analysis in both positive ion mode and negative ion mode. Each bubble in the bubble diagram represents a metabolic pathway, the horizontal axis where the bubble is located and the bubble size indicate the size of the influence factor of that pathway in the analysis, and the vertical axis where the bubble is located and the bubble color indicate the P-value of the enrichment analysis (taking the negative natural logarithm, namely −ln(p)). POS: positive ion mode; NEG, negative ion mode; ASCI, the acute-phase spinal cord injury.