TABLE 3.

The top fifteen downregulated differentially expressed metabolites (DEMs).

Metabolite	Log2 fold change	VIP	P-Value
Adenosine	–3.440	1.455	0.0004
Adenine	–2.927	1.362	0.0292
Adenosine monophosphate	–2.693	1.362	0.0145
Deoxyguanosine	–2.511	1.523	0.0016
N-a-Acetyl-L-arginine	–1.747	1.456	0.0029
Nicotinic acid mononucleotide	–1.745	1.498	0.0035
Phosphocreatine	–1.729	1.365	0.0160
2-Hydroxyethanesulfonate	–1.463	1.520	5.41E−07
Oxoadipic acid	–1.314	1.527	2.47E−05
N6-Acetyl-L-lysine	–1.312	1.356	0.0200
Molybdopterin precursor Z	–1.230	1.073	0.0149
Inosinic acid	–1.068	1.110	0.0120
Guanosine monophosphate	–1.060	1.001	0.0388
5-Aminoimidazole ribonucleotide	–1.043	1.166	0.0184
Menadiol disulfate	–1.027	1.279	0.0108