Table 1.
Shared neoantigens based on EGFR L858R and E746_A750del.
| EGFR mutation | EGFR neoepitope | HLA restriction | IC50 MT (nM) | IC50 WT (nM) | shared frequency (%) |
|---|---|---|---|---|---|
| L858R | HVKITDFGR | A*31:01 | 18.9 | 11653.7 | 1.19 |
| A*33:03 | 22.9 | 12734.0 | 2.93 | ||
| A*68:01 | 19.6 | 8625.5 | 0.28 | ||
| RAKLLGAEEK | A*30:01 | 47.5 | 881.9 | 1.71 | |
| E746_A750del | IPVAIKTSPK | A*11:01 | 158.2 | 31132.7 | 5.60 |
| A*03:01 | 70.7 | 30763.0 | 0.63 | ||
| A*03:02 | 376.4 | 29825.9 | 0.05 | ||
| A*11:02 | 158.2 | 31132.7 | 0.48 | ||
| A*11:20 | 65.1 | 26653.4 | 0.03 | ||
| A*68:01 | 429.6 | 11669.5 | 0.16 | ||
| AIKTSPKANK | A*30:01 | 355.0 | 5721.5 | 1.00 |