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. 2022 Nov 23;14:1056312. doi: 10.3389/fnagi.2022.1056312

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Copyright © 2022 He, Cong, Liang, Ma, Tian, Li and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prediction of marker gene-targeted drugs. A total of 117 drugs were retrieved that acted on the Hub gene. Of these, 30 drugs targeted ALOX15B and PPARD; 21 drugs targeted CDKN2A; 12 drugs targeted BRD4; 11 drugs acted on HMGB1; 9 drugs acted on P4HB; and 6 drugs targeted BAP1, respectively. Where red orbs represent up-regulated mRNA, green orbs represent down-regulated mRNA, and purple orbs represent drugs.