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. 2022 Nov 23;14:1056312. doi: 10.3389/fnagi.2022.1056312

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Copyright © 2022 He, Cong, Liang, Ma, Tian, Li and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The differential expression analysis results are shown in the volcano plot. The x-axis represents log2 (fold change), and the y-axis represents -log10 (adjust p-value). Green triangles represent downregulated genes, red triangles represent upregulated genes, and black dots represent genes with no evident differential expression. (B) Heatmap of FRDEGs. Each column in the graph represents a sample, each row represents a gene, and the expression status of the gene is indicated from high to low in orange to blue, respectively, and at the top of the heat map, blue/red represents the AD group/control group, respectively. (C) Shows the top 5 significantly enriched BP (biological process). (D) Shows the top 5 enriched CC (cellular component) considerably. (E) The top 5 enriched MF much (molecular function) are shown. (F) The top 5 significantly enhanced KEGG pathways. In the bubble plots for GO and KEGG enrichment analysis, blue dots represent genes, red dots represent pathways, and bubble size represents the number of genes enriched in that pathway. AD, Alzheimer’s disease; Control, healthy control; FRDEGs, Ferroptosis-related differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.