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. 2022 Aug 2;18(3):587–593. doi: 10.4103/1673-5374.347740

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Copyright: © Neural Regeneration Research

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Investigation of serum exosome characteristics between MCI patients and healthy controls.

(A) Serum exosome extracted from healthy controls (left) and MCI patients (right), which was detected using transmission electron microscopy. The arrows indicate isolated vesicles. Bar = 100 nm. (B) Western blot shows proteins isolated from U87 cells or extracted from serum exosomes of a healthy control (Con11) and an MCI patient (MCI11), in which exosome (Exo) markers (CD9, CD63, and TSG101) and the endoplasmic reticulum (ER) marker (Calnexin) were detected. (C) Nanoparticle tracking analysis shows that the mode of serum exosomes from MCI patients was smaller than that of healthy controls (healthy control n = 20, MCI n =20). *P < 0.05, vs. Control (D) Nanoparticle tracking analysis shows that the serum exosome concentration from MCI patients was higher than that of healthy controls (healthy control, n = 20; MCI, n = 20 ) (**P < 0.01, Welch’s t-test). Data were presented as the mean ± SD. MCI: Mild cognitive impairment.