Figure 3.

Identification of differentially expressed proteins from mild cognitively impaired patients and healthy controls.

(A) Venn diagrams suggest the total number of proteins detected in each group. There are 2317 proteins that overlap between the two groups. (B) A volcano plot demonstrates the differentially expressed proteins in MCI patients and healthy controls (fold-change > 1.5 and P < 0.05). (C) Heatmap showing the differentially expressed exosomal proteins in MCI patients and healthy controls. Each row represents a protein and each column represents a single individual. The protein expression level on the heatmap was reflected by different colors, where red represents high-expression proteins and green represents low-expression proteins. (D) Protein-protein interaction network of differentially expressed proteins between MCI patients and healthy controls, in which nodes stand proteins and lines represent connection. The node color gradation reflects the quantity of interacting proteins. MCI: Mild cognitive impairment.