Table 2.
The diagnostic capacity of the top-20 candidate serum biomarkers for distinguishing between health controls (HC) and mild cognitive impairment (MCI) patients
| Protein | MCI (n = 20) vs. Control (n = 20) | P-vaule | ||
|---|---|---|---|---|
|
| ||||
| SEN (%) | SPE (%) | AUC | ||
| Precursor (AA -19 to 108) (fragment) | 85.0 | 73.7 | 0.834 | 0.002 |
| Fibulin-1 | 65.0 | 85.0 | 0.810 | 0.005 |
| Protein tweety homolog 3 (TTYH3) | 86.7 | 66.7 | 0.794 | 0.023 |
| Actin, cytoplasmic 1 | 85.0 | 70.0 | 0.787 | 0.013 |
| Properdin (PFC) | 80.0 | 70.0 | 0.775 | 0.009 |
| Integrin beta-3 | 55.0 | 93.8 | 0.775 | 0.016 |
| Beta-parvin | 81.3 | 69.2 | 0.774 | 0.025 |
| Talin-1 | 90.0 | 52.9 | 0.738 | 0.024 |
| Moesin | 73.7 | 70.6 | 0.731 | 0.008 |
| Band 3 anion transport protein | 55.0 | 89.5 | 0.726 | 0.002 |
| Reelin | 60.0 | 82.4 | 0.726 | 0.016 |
| Actin, alpha cardiac muscle 1 | 57.9 | 90.9 | 0.713 | 0.046 |
| RAP1B | 70.0 | 69.2 | 0.708 | 0.049 |
| Integrin alpha-IIb | 50.0 | 94.7 | 0.703 | 0.013 |
| L-lactate dehydrogenase B chain (LDH-B) | 62.5 | 73.3 | 0.700 | 0.023 |
| Rheumatoid factor G9 heavy chain (fragment) | 64.7 | 84.2 | 0.693 | 0.035 |
| Coagulation factor XI | 95.0 | 36.8 | 0.676 | 0.023 |
| Immunoglobulin delta heavy chain | 52.6 | 84.2 | 0.670 | 0.025 |
| Uncharacterized protein | 65.0 | 61.1 | 0.661 | 0.046 |
| von Willebrand factor | 35.0 | 95.0 | 0.657 | 0.045 |