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. 2022 Aug 2;18(3):634–642. doi: 10.4103/1673-5374.350210

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Copyright: © Neural Regeneration Research

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SPARC-null mice exhibit motor dysfunction.

(A) Residence time on the stick in the rotating rod test. (B) The inclined plate score in the inclined plate test. (C) The pain threshold in the pain threshold test. (D, E) The BMS main (D) and sub (E) scores. (F) Running speed based on gait analysis before sampling. Data are shown as mean ± SD (n = 11 in the SPARC-null group, n = 10 in the WT group). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (Student’s t-test). BMS: Basso Mouse Scale; SPARC: secreted protein, acidic and rich in cysteine; WT: wild-type.