Table 2.

Noggin treatment in animal models of spinal cord injury

Animal model	Mode of spinal cord injury	Noggin treatment	Dose and route of administration	Duration	References
Sprague-Dawley rats (female)	Contusion injury at T7	Recombinant human Noggin protein	1.2–2.4 μg/d intrathecal injections	3 d to 10 wk	Hart et al., 2020
Mice (female)	Contusion injury at T8 and T9	Recombinant mouse Noggin protein	15 ng/kg/d intrathecal injection with osmotic minipump	1 wk	Xiao et al., 2010
Sprague-Dawley rats	Transection injury at T10	Recombinant Noggin protein	1 µg/kg noggin injection	1 to 7 d	Cui et al., 2015
Sprague-Dawley rats (female)	Contusion injury at T9–T10	Recombinant mouse Noggin protein	17.8 μg/kg/d intrathecal injection with osmotic minipump	2 wk	Matsuura et al., 2008
Adult Sprague-Dawley rats (male)	Ligation of spinal nerve ligation at L5 (an animal model of neuropathic pain)	Recombinant Noggin protein	5 µg/mL intrathecal injection	1 to 7 d	Yang et al., 2019