Table 2.
Predicted top 10 drug compounds targeting ferroptosis to repair SCI
| Drugs | CTD No. | P-value | Genes |
|---|---|---|---|
| 1,9-Pyrazoloanthrone | 00003948 | 3.31E-18 | Stat3, Jun, Hmox1, Atf3, Ptgs2, Rela, Mapk1, Mapk9, Vegfa |
| Capsaicin | 00005570 | 1.08E-17 | Stat3, Jun, Hmox1, Atf3, Ptgs2, Rela, Mapk1, Mapk9, Vegfa |
| Curcumin | 00000663 | 1.51E-16 | Stat3, Jun, Hmox1, Atf3, Ptgs2, Rela, Mapk1, Mapk9, Vegfa, Tlr4 |
| Dibenziodolium | 00000351 | 1.51E-16 | Stat3, Hmox1, Ptgs2, Rela, Mapk1, Mapk9, Vegfa |
| Simvastatin | 00007319 | 3.80E-16 | Stat3, Jun, Hmox1, Atf3, Ptgs2, Rela, Mapk1, Tlr4, Vegfa |
| N-Acetyl-L-cysteine | 00005305 | 5.25E-16 | Stat3, Jun, Hmox1, Ptgs2, Rela, Mapk1, Mapk9, Tlr4, Vegfa |
| Go 6976 | 00002962 | 3.82E-15 | Jun, Hmox1, Mapk1, Ptgs2, Rela, Vegfa |
| Fenretinide | 00007166 | 1.11E-14 | Jun, Hmox1, Atf3, Mapk1, Mapk9, Ptgs2, Rela, Vegfa |
| Acetovanillone | 00002374 | 1.66E-14 | Jun, Hmox1, Mapk1, Mapk9, Ptgs2, Rela |
| Bortezomib | 00003736 | 2.53E-14 | Stat3, Jun, Hmox1, Atf3, Ptgs2, Rela, Mapk1, Mapk9, Vegfa, Tlr4 |
ATF3: Activating transcription factor 3; HMOX1: heme oxygenase 1; JUN: Jun proto-oncogene; MAPK1: mitogen-activated protein kinase 1; MAPK9: mitogen-activated protein kinase 9; PTGS2: prostaglandin-endoperoxide synthase 2; RELA: RELA proto-oncogene; STAT3: signal transducer and activator of transcription 3; TLR4: Toll-like receptor 4; VEGFA: vascular endothelial growth factor A.