Additional Table 4.
TOP 20 KEGG enrichment analysis of ferroptosis genes identified 1, 3 and 7 days after SCI
| KEGG Pathway | Description | Count | P. adjust |
|---|---|---|---|
| SCI-1 day | |||
| rno04933 | AGE-RAGE signaling pathway in diabetic complications | 10 | 3.39686E-09 |
| rno05167 | Kaposi sarcoma-associated herpesvirus infection | 11 | 1.90865E-07 |
| rno04137 | Mitophagy -animal | 7 | 9.81957E-07 |
| rno05161 | Hepatitis B | 9 | 1.29788E-06 |
| rno05212 | Pancreatic cancer | 7 | 1.40215E-06 |
| rno04621 | NOD-like receptor signaling pathway | 9 | 2.548E-06 |
| rno04926 | Relaxin signaling pathway | 8 | 2.548E-06 |
| rno04620 | Toll-like receptor signaling pathway | 7 | 4.30704E-06 |
| rno05142 | Chagas disease | 7 | 8.43727E-06 |
| rno04659 | T helper 17 cell differentiation | 7 | 8.43727E-06 |
| rno04217 | Necroptosis | 8 | 8.43727E-06 |
| rno04625 | C-type lectin receptor signaling pathway | 7 | 8.43727E-06 |
| rno04668 | TNF signaling pathway | 7 | 8.43727E-06 |
| rno04066 | HIF-1 signaling pathway | 7 | 9.8693E-06 |
| rno05133 | Pertussis | 6 | 1.04369E-05 |
| rno04917 | Prolactin signaling pathway | 6 | 1.14226E-05 |
| rno04216 | Ferroptosis | 5 | 1.17663E-05 |
| rno05140 | Leishmaniasis | 6 | 1.27069E-05 |
| rno04068 | FoxO signaling pathway | 7 | 1.69572E-05 |
| rno04210 | Apoptosis | 7 | 2.16673E-05 |
| SCI-3 day | |||
| rno05161 | Hepatitis B | 7 | 0.000286916 |
| rno04933 | AGE-RAGE signaling pathway in diabetic complications | 6 | 0.000286916 |
| rno04668 | TNF signaling pathway | 6 | 0.000323416 |
| rno04621 | NOD-like receptor signaling pathway | 7 | 0.000324954 |
| rno04216 | Ferroptosis | 4 | 0.000719916 |
| rno05167 | Kaposi sarcoma-associated herpesvirus infection | 7 | 0.000719916 |
| rno04217 | Necroptosis | 6 | 0.001150192 |
| rno04066 | HIF-1 signaling pathway | 5 | 0.002262217 |
| rno05206 | MicroRNAs in cancer | 7 | 0.002463119 |
| rno05321 | Inflammatory bowel disease | 4 | 0.002463119 |
| rno04137 | Mitophagy -animal | 4 | 0.002463119 |
| rno04068 | FoxO signaling pathway | 5 | 0.002722106 |
| rno04210 | Apoptosis | 5 | 0.003177702 |
| rno05140 | Leishmaniasis | 4 | 0.003601617 |
| rno04211 | Longevity regulating pathway | 4 | 0.004824311 |
| rno05163 | Human cytomegalovirus infection | 6 | 0.004824311 |
| rno05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 4 | 0.004824311 |
| rno05166 | Human T-cell leukemia virus 1 infection | 6 | 0.004824311 |
| rno04657 | IL-17 signaling pathway | 4 | 0.004824311 |
| rno05323 | Rheumatoid arthritis | 4 | 0.004824311 |
| SCI-7 day | |||
| rno04933 | AGE-RAGE signaling pathway in diabetic complications | 8 | 8.98331E-09 |
| rno05161 | Hepatitis B | 7 | 4.96225E-06 |
| rno04621 | NOD-like receptor signaling pathway | 7 | 8.11253E-06 |
| rno04066 | HIF-1 signaling pathway | 6 | 9.71798E-06 |
| rno04137 | Mitophagy -animal | 5 | 1.21857E-05 |
| rno04926 | Relaxin signaling pathway | 6 | 1.21857E-05 |
| rno05167 | Kaposi sarcoma-associated herpesvirus infection | 7 | 1.21857E-05 |
| rno05212 | Pancreatic cancer | 5 | 1.64876E-05 |
| rno04217 | Necroptosis | 6 | 3.1441E-05 |
| rno05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 5 | 3.34776E-05 |
| rno04620 | Toll-like receptor signaling pathway | 5 | 3.54104E-05 |
| rno04216 | Ferroptosis | 4 | 3.54104E-05 |
| rno05142 | Chagas disease | 5 | 5.68752E-05 |
| rno04659 | T helper 17 cell differentiation | 5 | 5.68752E-05 |
| rno04068 | FoxO signaling pathway | 5 | 0.000137349 |
| rno05169 | Epstein-Barr virus infection | 6 | 0.000144326 |
| rno04210 | Apoptosis | 5 | 0.000144326 |
| rno05321 | Inflammatory bowel disease | 4 | 0.000144326 |
| rno05170 | Human immunodeficiency virus 1 infection | 6 | 0.000144326 |
| rno05162 | Measles | 5 | 0.000182433 |
AGE-RAGE: Advanced glycation end products-receptor for advanced glycation end products; FoxO: Forkhead box O; HIF-1: hypoxia inducible factor 1; IL-17: interleukin-17; KEGG: Kyoto Encyclopedia of Genes and Genomes; NOD-like: nucleotide oligomerization domain-like; PD-1: programmed cell death-1; PD-L1: programmed cell death-ligand 1; SCI: spinal cord injury; TNF: tumor necrosis factor.