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. 2022 Aug 2;18(3):657–663. doi: 10.4103/1673-5374.350212

Figure 4.

Figure 4

Effect of the granular hydrogel nerve guidance conduit on the FG-labeled motoneurons in the spinal anterior horn of rats with sciatic nerve injury 16 weeks after surgery.

(A) The distribution of the FG-labeled motoneurons (arrowheads) in the spinal anterior horn. Groups G (G1 and G2) and A (A1 and A2) showed more labeled neurons than Groups C (C1 and C2) and B (B1 and B2). A2, G2, C2, and B2 are the zoomed-in fields of A1, G1, C1, and B1, respectively. Scale bars: 1 mm (upper), 200 µm (lower). (B) The number of FG-labeled motoneurons on 10 spinal cord slices from each animal. Data are shown as the mean ± SD (n = 3). **P < 0.01, ***P < 0.001, vs. Group G; ##P < 0.01, ###P < 0.001, vs. Group A; $$$P < 0.001, vs. Group C (one-way analysis of variance followed by Tukey’s post hoc test). FG: Fluoro-gold; Group A: autologous nerve group; Group B: bulk hydrogel group; Group C: chitosan conduit group; Group G: granular hydrogel group.