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. 2022 Jun 2;18(3):519–520. doi: 10.4103/1673-5374.346486

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Copyright: © Neural Regeneration Research

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SARS-CoV-2 getting into the brain.

(A) Exploring the possibilities of mutated SARS-CoV-2 getting into the brain via crossing blood-brain, blood-cerebrospinal fluid, and blood-retinal barrier. (B) The interaction of SARS-CoV-2 with the neuronal system can affect brain function to cause cells, tissue, or both damage via causing neuroinflammation, affecting the defense capability of genes, and injuring brain muscle. (C) Proposing nano-theranostics involve efficient diagnostics tools, personalized nanomedicine, natural therapeutics agents, combinational long-term therapies needed to trap and eradicate SARS-CoV-2. (D) An optimized combination of nano-theranostics approaches can manage neuroCOVID-19 in personalized management. COVID-19: Coronavirus disease 2019; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.