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. 2022 Aug 2;18(3):603–608. doi: 10.4103/1673-5374.350204

Figure 7.

Figure 7

Silence of β2M reduces NLRP3 inflammasome activation and pro-inflammatory cytokine production in ischemic cerebral cortexes.

(A) NLRP3, ASC, caspase-1 (p20), IL-1β, IL-6 and TNFα proteins were detected using western blotting. (B, C) Quantitative results of protein levels normalized to β-actin. Data are presented as means ± SEM (n = 4). ***P < 0.01, ****P < 0.001, vs. sham group; ##P < 0.01, ###P < 0.001, ####P < 0.0001, vs. MCAO + SC group (one-way analysis of variance followed by Tukey’s honestly significant difference post hoc test). ASC: Apoptosis-associated speck-like protein containing a CARD; IL-1β: interleukin-1β; IL-6: interleukin-6; MCAO: middle cerebral artery occlusion; NLRP3: Nod-like receptor pyrin domain containing 3; RNAi: RNA interference; SC: scramble control; TNFa: tumor necrosis factor alpha; β2M: β2 microglobulin.