Table 1.
Various case studies regarding trigeminal neuralgia as an initial presentation of systemic autoimmune diseases.
| Study | Number of patients | Age | Sex | Laterality of TN | TN to CTD Diagnosis duration (months) | Diagnosis | Treatment | Improvement of TN symptoms |
|---|---|---|---|---|---|---|---|---|
| Kabadi UM et al., 1977 (22) | 1 | 41 | F | U/L | 60 | CREST | C | Partial |
| syndrome | ||||||||
| Bennett RM et al.,1978 (28) | 1 | 34 | F | U/L | 12 | MCTD | P | No |
| Searles et al., 1978 (20) | 1 | 38 | F | B/L | 0 | MCTD | P | Partial |
| Burke MJ et al., 197912 | 3 | 63 | F | U/L | 24 | SSc | Pencillamine | No |
| 22 | M | U/L | 1 | |||||
| 36 | M | U/L | 24 | |||||
| Teasdall RD et al., 19809 | 5 | 43 | M | U/L | 24 | SSc | NA | No |
| 51 | F | U/L | 60 | NA | No | |||
| 55 | F | U/L | 18 | NA | No | |||
| 52 | F | U/L | 12 | NA | No | |||
| 63 | F | U/L | 12 | NA | No | |||
| Edmondstone WM et al.,19825 | 1 | 25 | M | U/L | 13 | MCTD | P | Partial |
| Heald A et al., 198910 | 1 | 58 | M | B/L | 72 | SSc | Penicillamine, Naproxen | No |
| Varga et al.,199018 | 1 | 39 | M | B/L | NA | MCTD | P,A | Partial |
| Alfaro-Giner A et al., 199226 | 1 | 41 | F | U/L | 2 | MCTD | P/C | No |
| Hojaili B et al., 20064 | 1 | 46 | F | B/L | 2 | MCTD | C/G/P/A | No |
| Ribeiro RT et al., 20098 | 2 | 42 | M | U/L | 12 | SSc | G/N/M/P | Partial |
| 50 | F | U/L | 10 | A/P/M | No | |||
| Hamoir et al., 201424 | 1 | 59 | F | U/L | 0 | MCTD | P/HCQ | NA |
| Danve et al., 201825 | 1 | 55 | F | B/L | 0 | MCTD | P/IV IG | Partial |
| Yuan J et al., 201815 | 1 | 30 | F | U/L | 0 | pSS | P/C | Yes |
| Jeemon G et al., 202227 | 1 | 32 | F | U/L | 4 | MCTD | C | Yes |
C: Carbamazepine; G: Gabapentin; P: Prednisolone; A: Azathioprine; M: Methotrexate; N: Nortriptyline; IV IG: Intravenous immunoglobulin; HCQ: Hydroxychloroquine; TN: Trigeminal Neuralgia; MCTD: Mixed connective tissue; pSS: Primary Sjögren’s syndrome; SSc: Systemic sclerosis; U/L: Unilateral; B/L: Bilateral; NA: Not available.