TABLE 2.

Ab responses to P. falciparum blood-stage epitopes correlated with age

Isotype(s)	Sampleb	Ab levels to antigena
		Peptide RESA	Peptide MSP1-Nt	Peptide MSP2-Nt	Peptide MSP2-Ct1	Peptide MSP2-Ct2	Extract
IgG1	P1	NS	NS	NS	NS	NS	0.28 (<10−4)
	P2	NS	NS	NS	0.20 (0.002)	NS	0.16 (0.015)
IgG2	P1	0.51 (<10−4)	0.43 (<10−4)	0.42 (<10−4)	0.39 (<10−4)	0.40 (<10−4)	0.59 (<10−4)
	P2	0.56 (<10−4)	0.57 (<10−4)	0.58 (<10−4)	0.61 (<10−4)	0.63 (<10−4)	0.65 (<10−4)
IgG3	P1	0.24 (0.001)	0.29 (<10−4)	0.30 (<10−4)	0.31 (<10−4)	0.17 (0.016)	0.54 (<10−4)
	P2	0.22 (0.001)	0.22 (0.001)	0.23 (<10−3)	0.20 (0.002)	0.24 (<10−3)	0.40 (<10−4)
IgG4	P1	NS	NS	NS	NS	NS	0.20 (0.004)
	P2	NS	NS	−0.14 (0.030)	NS	NS	0.19 (0.004)
IgG	P1	0.15 (0.029)	0.16 (0.025)	NS	NS	NS	0.47 (<10−4)
	P2	0.38 (<10−4)	0.24 (<10−4)	0.35 (<10−4)	0.27 (<10−4)	0.29 (<10−4)	0.41 (<10−4)
IgG1/IgG4	P1	NS	NS	NS	NS	NS	NS
	P2	0.14 (0.029)	NS	0.21 (0.001)	0.20 (0.002)	0.15 (0.020)	NS
IgG2/IgG4	P1	0.16 (0.024)	NS	NS	NS	0.18 (0.011)	0.50 (<10−4)
	P2	0.44 (<10−4)	0.38 (<10−4)	0.46 (<10−4)	0.48 (<10−4)	0.50 (<10−4)	0.46 (<10−4)
IgG3/IgG4	P1	NS	NS	NS	NS	0.15 (0.032)	0.33 (<10−4)
	P2	0.25 (<10−4)	0.21 (0.001)	0.29 (<10−4)	0.25 (<10−4)	0.29 (<10−4)	0.26 (<10−4)

^aResults are expressed as Spearman's correlation coefficient. The levels of significance are given in parentheses. NS, not significant. 

^bBlood samples were taken before the season of transmission (P1) and at the end of the season of transmission (P2).