Table 5.
Prognostic factors of patients with gastric cancer by univariate and multivariate analyses based on Cox regression analysis in the Chinese validation cohort
| Characteristics |
Multivariate analysis, pT1
|
Multivariate analysis, pT2
|
Multivariate analysis, pT3
|
Multivariate analysis, pT4
|
||||
|
HR (95%CI)
|
P
value
|
HR (95%CI)
|
P
value
|
HR (95%CI)
|
P
value
|
HR (95%CI)
|
P
value
|
|
| Sex | - | - | - | - | ||||
| Male | ||||||||
| Female | ||||||||
| Age | 1.056 (1.030-1.082) | < 0.001 | 1.048 (1.024-1.072) | < 0.001 | 1.016 (1.007-1.025) | < 0.001 | 1.021 (1.013-1.029) | < 0.001 |
| Tumor location | 0.034 | - | 0.122 | - | ||||
| Upper third | 1 | 1 | ||||||
| Middle third | 0.384 (0.151-0.972) | 0.043 | 0.828 (0.623-1.100) | 0.192 | ||||
| Lower third | 0.413 (0.209-0.815) | 0.011 | 0.783 (0.619-0.989) | 0.040 | ||||
| Tumor size (mm) | - | - | < 0.001 | < 0.001 | ||||
| ≤ 50 | 1 | 1 | ||||||
| > 50 | 1.435 (1.201-1.715) | 1.422 (1.209-1.671) | ||||||
| Histological type | - | - | 0.260 | - | ||||
| Well-moderately differentiated | 1 | |||||||
| Poorly-undifferentiated | 1.133 (0.934-1.374) | 0.204 | ||||||
| Signet ring cell | 1.305 (0.993-1.374) | 0.056 | ||||||
| Others | 1.037 (0.993-1.716) | 0.851 | ||||||
| MLNs | 1.224 (1.133-1.322) | < 0.001 | 1.067 (1.049-1.086) | < 0.001 | 1.063 (1.052-1.073) | < 0.001 | 1.053 (1.044-1.063) | < 0.001 |
| RLNs | 0.976 (0.954-0.999) | 0.044 | 0.979 (0.960-0.999) | 0.037 | 0.988 (0.979-0.996) | 0.003 | 0.974 (0.967-0.981) | < 0.001 |
| Chemotherapy | - | - | - | - | ||||
| Yes | ||||||||
| No/unknown | ||||||||
-: Univariate analysis was not statistically significant; RLNs: Retrieved lymph nodes; MLNs: Metastatic lymph nodes.