Table 6.
Prognostic factors of patients with gastric cancer by univariate and multivariate analyses based on Cox regression analysis in the Surveillance, Epidemiology, and End Results validation cohort
|
Characteristics
|
Multivariate analysis, pT1
|
Multivariate analysis, pT2
|
Multivariate analysis, pT3
|
Multivariate analysis, pT4
|
||||
|
HR (95%CI)
|
P
value
|
HR (95%CI)
|
P
value
|
HR (95%CI)
|
P
value
|
HR (95%CI)
|
P
value
|
|
| Sex | 0.001 | - | - | - | ||||
| Male | 1 | |||||||
| Female | 0.712 (0.596-0.851) | |||||||
| Age | 1.044 (1.035-1.052) | < 0.001 | 1.032 (1.024-1.040) | < 0.001 | 1.018 (1.014-1.022) | < 0.001 | 1.018 (1.014-1.022) | < 0.001 |
| Tumor location | < 0.001 | < 0.001 | - | 0.007 | ||||
| Upper third | 1 | 1 | 1 | |||||
| Middle third | 0.491 (0.364-0.661) | < 0.001 | 0.671 (0.496-0.908) | 0.010 | 0.883 (0.718-1.085) | 0.235 | ||
| Lower third | 0.636 (0.534-0.758) | < 0.001 | 0.603 (0.501-0.726) | < 0.001 | 1.122 (0.963-1.308) | 0.140 | ||
| Tumor size (mm) | - | 0.004 | < 0.001 | < 0.001 | ||||
| ≤ 50 | 1 | 1 | 1 | |||||
| > 50 | 1.323 (1.091-1.604) | 1.172 (1.079-1.274) | 1.285 (1.157-1.427) | |||||
| Histological type | - | - | - | - | ||||
| Well-moderately differentiated | ||||||||
| Poorly-undifferentiated | ||||||||
| Signet ring cell | ||||||||
| Others | ||||||||
| MLNs | 1.111 (1.088-1.135) | < 0.001 | 1.022 (1.013-1.030) | < 0.001 | 1.024 (1.021-1.027) | < 0.001 | 1.035 (1.030-1.039) | < 0.001 |
| RLNs | 0.978 (0.969-0.986) | < 0.001 | 0.981 (0.973-0.990) | < 0.001 | 0.986 (0.983-0.990) | < 0.001 | 0.973 (0.969-0.978) | < 0.001 |
| Chemotherapy | - | 0.002 | - | - | ||||
| Yes | 1 | |||||||
| No/unknown | 1.323 (1.110-1.577) | |||||||
-: Univariate analysis was not statistically significant; RLNs: Retrieved lymph nodes; MLNs: Metastatic lymph nodes; HR: Hazard ratio; CI: Confidence interval.