Table 3.

Comparison of symptom burden and health-related quality of life in the experimental and control groups.

Scale		iMBCRa group, mean (SD)	Control group, mean (SD)	Cohen d		Linear mixed model statistical tests
						Difference in mean change from baseline between groupsb					Group effect							Time effect											Group×time
						Score (95% Cl)		P value			F test (df)			P value				F test (df)							P value			F test (df)							P value
MDASIc total score												5.55 (1,95)				.02				65.31 (2,100)						<.001				9.86 (2,100)						<.001
	T0d	63.12 (20.37)	61.44 (19.58)	N/Ae		N/A		N/A
	T1f	45.11 (13.30)	54.78 (16.46)	–0.65		–11.67 (–16.99 to –6.36)		<.001
	T2g	39.14 (9.95)	49.13 (10.43)	–0.98		–11.83 (–18.19 to –5.46)		<.001
MDASI symptom-severity score												4.91 (1,102)				.03				69.61 (2,100)						<.001				11.73 (2,100)						<.001
	T0	45.43 (13.79)	43.35 (14.74)	N/A		N/A		N/A
	T1	31.87 (8.85)	38.53 (10.43)	–0.69		–8.87 (–12.54 to –5.21)		<.001
	T2	26.92 (7.49)	34.27 (7.79)	–0.96		–9.51 (–14.19 to –4.82)		<.001
MDASI symptom-interference score												4.56 (1,161)				.03				20.81 (2,121)						<.001				1.37 (2,121)						.26
	T0	17.69 (9.78)	18.10 (7.24)	N/A		N/A		N/A
	T1	13.23 (6.41)	16.24 (7.30)	–0.44		–2.67 (–6.14 to 0.79)		.13
	T2	12.22 (4.20)	14.86 (3.68)	–0.67		–2.30 (–5.14 to 0.54)		.11
FACT-Bh total score												6.55 (1,96)				.01				36.49 (2,100)						<.001				14.82 (2,100)						<.001
	T0	82.64 (15.74)	82.86 (16.27)	N/A		N/A		N/A
	T1	90.07 (13.74)	84.04 (11.52)	0.48		6.66 (3.43 to 9.90)		<.001
	T2	98.00 (7.51)	86.52 (10.88)	1.23		11.94 (7.56 to 16.32)		<.001
Physical well-being												1.88 (1,101)				.17				20.48 (2,99)				<.001						5.18 (2,99)				.007
	T0	19.41 (4.23)	19.63 (5.41)	N/A		N/A		N/A
	T1	21.38 (3.60)	20.20 (4.66)	0.28		1.50 (0.38 to 2.62)		.009
	T2	22.88 (2.02)	20.86 (4.76)	0.55		2.31 (0.87 to 3.76)		.002
Emotional well-being												0.41 (1,101)				.53				25.42 (2,96)				<.001						2.20 (2,96)				.12
	T0	15.20 (4.81)	15.35 (4.34)	N/A		N/A		N/A
	T1	16.46 (3.58)	16.32 (3.97)	0.04		0.35 (–0.66 to 1.36)		.50
	T2	18.46 (1.95)	17.26 (3.59)	0.42	1.38 (–0.05 to 2.81)		.06
Functional well-being										3.22 (1,102)					.08				5.25 (2,90)				.007						4.89 (2,90)				.01
	T0	11.73 (4.74)	11.66 (4.77)	N/A	N/A		N/A
	T1	12.36 (4.78)	10.10 (4.36)	0.49	1.31 (0.14 to 2.48)		.03
	T2	14.06 (2.68)	11.48 (4.32)	0.72	2.52 (0.90 to 4.15)		.003
Social well-being										2.33 (1,101)					.13				2.02 (2,96)				.14						1.51 (2,96)				.23
	T0	17.19 (5.31)	16.86 (5.21)	N/A	N/A		N/A
	T1	17.87 (4.84)	16.58 (3.70)	0.30	1.03 (–0.23 to 2.29)		.11
	T2	18.69 (3.03)	16.98 (3.58)	0.52	1.41 (–0.38 to 3.21)		.12
Breast cancer–specific subscale for additional concerns										33.41 (1,99)					<.001				46.72 (2,196)				<.001						29.33 (2,196)									<.001
	T0	19.12 (2.42)	19.37 (2.39)	N/A	N/A		N/A
	T1	22.00 (2.37)	19.94 (2.33)	0.88	2.36 (1.26 to 3.47)		<.001
	T2	23.92 (2.16)	19.94 (2.48)	1.70	4.28 (3.18 to 5.39)		<.001

^aiMBCR: internet-delivered mindfulness-based cancer recovery.

^bDifference in mean change from baseline to end point between the groups.

^cMDASI: MD Anderson Symptom Inventory.

^dT0: baseline.

^eN/A: not applicable.

^fT1: after the intervention.

^gT2: 1-month follow-up.

^hFACT-B: Functional Assessment of Cancer Therapy-Breast.