Fig. 7.

HY08 treatment inhibits BAX protein expression and upregulates Bcl-2 expression in I/R mice. (A–D) Representative Western blots (A). Quantitative analyses of BAX (B) and Bcl-2 (C) protein expression and the BAX/Bcl-2 ratio (D) in contralateral and ipsilateral brain regions. The data shown in each column represent the mean ± SEM. *p < 0.05, **p < 0.01 vs. vehicle-treated sham group (contralateral/ipsilateral); ^#p < 0.05, ^##p < 0.01 vs. vehicle-treated I/R group (contralateral/ipsilateral) (n = 4). (E–G) Representative immunofluorescence staining of TOM20, FABP3, or FABP5 (green) with BAX (red) in the cortical penumbra of HY08-treated or untreated I/R mice. Scale bar = 100 μm. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)