Table 2.
Photolysis (5 mW LED at 365 nm) of alkyl-Cbls in DMF.
| ß-axial Substituent | K OW a | k (s−1)b | Φc | |
|---|---|---|---|---|
| 4 | ethyl | 1.33 | 0.14 ± 0.02 | 0.46 ± 0.08 |
| 7 | decyl | 4.67 | 0.09 ± 0.02 | 0.29 ± 0.05 |
| 8 | cyclopropyl | 1.25 | 0.057 ± 0.009 | 0.19 ± 0.03 |
| 12 | cyclohexylmethyl | 2.83 | 0.12 ± 0.01 | 0.40 ± 0.01 |
| 15 | 1-amino-1-carboxypropyl | −0.41 | 0.036 ± 0.005 | 0.12 ± 0.02 |
a
The octanol water partition coefficient was calculated using ChemDraw 20.0.
b
Initial rate of photolysis from the average of three photolysis trials per conjugate.
c
The quantum yields were calculated using methyl-Cbl as the actinometer.38