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. Author manuscript; available in PMC: 2023 Apr 15.
Published in final edited form as: J Org Chem. 2022 Mar 30;87(8):5076–5084. doi: 10.1021/acs.joc.1c02931

Table 3.

Photolysis (0.025 mW output Xe arc lamp at 505 or 550 nm) of ethyl-Cbl and ethyl-Cbl-linker-fluorophore in phosphate buffered saline.

Linker Fluorophore Relative
Rate		 Rate
(min−1)
Fitzpatrick
I/IIc 		Rate
(min−1)
Fitzpatrick
III/IVc 		Rate
(min−1)
Fitzpatrick
V/VIc
- - 1 0.13 ± 0.01 0.09 ± 0.01 0.11 ± 0.02
EDA Bodipy a 4.3 ± 0.7 - - -
DACH Bodipy a 3.1 ± 0.5 - - -
EDA Cy3 b 4.5 ± 0.6 - - -
DACH Cy3 b 3.1 ± 0.3 - - -
EDA TAMRA b 4.0 ± 0.4 0.56 ± 0.08 0.44 ± 0.05 0.32 ± 0.02
DACH TAMRA b 2.8 ± 0.4 - - -
a

Photolysis performed at 505 nm.

b

Photolysis performed at 550 nm.

c

Light from the Xe arc lamp source was pre-filtered through 2 cm of a Fitzpatrick phantom solution.