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[Preprint]. 2022 Nov 29:2022.11.29.518385. [Version 1] doi: 10.1101/2022.11.29.518385

Figure 3: Maternal IgG antibodies generated in response to vaccination are detected in umbilical cord plasma.

Figure 3:

(A) RBD-specific IgG titers in maternal circulation and umbilical cord plasma at delivery (n=45 pairs). (B) Correlation of peak levels of RBD-specific IgG antibodies in maternal circulation pre-delivery and UCB (n=41). (C) Comparison of antibody levels in UCB and maternal circulation (M) at delivery, by trimester of initial maternal vaccination (T1=10, T2=19, T3=14). (D) IgG isotype analysis of UCB (n=14 pairs). (E) Correlation between UCB and maternal RBD-specific IgG titers at delivery (n=45). (F) Correlation between UCB and peak RBD specific IgG in maternal circulation before delivery (n=41). (G) RBD-specific IgG titers in UCB relative to days since maternal first vaccine dose (n=48). * p < 0.03, ** p < 0.002, *** p < 0.0002, **** p<0.0001.