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[Preprint]. 2022 Nov 29:2022.11.29.518385. [Version 1] doi: 10.1101/2022.11.29.518385

Figure 4: Passively transferred antibodies are detected in newborn circulation.

Figure 4:

(A) Comparison (n=38 pairs) and (B) correlation (n=38) between UCB and newborn blood RBD-specific antibody titers. (C) Overall comparison between maternal RBD-specific IgG antibodies at delivery and newborn RBD-specific IgG titers, independent of trimester of initial vaccination, (n=35) and (D) RBD-specific IgG titers in maternal plasma (M) at delivery and newborn plasma stratified by trimester of initial maternal vaccination (T1, n=6; T2, n=20; T3, n=7). (E) Correlation (n=35) of RBD-specific IgG titers in newborn and maternal plasma at delivery. (F) IgG isotype analysis in newborn plasma (n=14 pairs). (G) RBD-specific IgG titers in newborn plasma relative to days post maternal vaccination (n=40). * p < 0.03, ** p < 0.002, *** p < 0.0002, **** p<0.0001.