Table 5. Optimization of the Gold(III)-Catalyzed Oxidative Coupling of Arenes and Aryl Silanes Using [AuI2(Me2dazdt)]I3 (1a) as the Catalyst.
| conditions |
yield (%)a |
|||||
|---|---|---|---|---|---|---|
| entry | catalyst loading (mol %) | concentration (M) | arene equivalence | temperature (°C) | 16 | 17 |
| 1 | 1 | 0.10 | 1 | r.t. | 15 | 18 |
| 2 | 2 | 0.10 | 1 | r.t. | 20 | 25 |
| 3 | 1 | 0.10 | 1 | 60 °C | 40 | 25 |
| 4b | 1 | 0.10 | 1 | 60 °C | 45 | 28 |
| 5c | 1 | 0.23 | 1.5 | 30 °C | 73 | 6 |
a
Yields are determined by HPLC.
b
Reaction is performed in the presence of AgSbF6 (6 mol %).
c
Final optimized conditions are extracted from a design of experiment optimization.