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. 2022 Nov 18;33(14):br28. doi: 10.1091/mbc.E22-03-0092

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FIGURE 4: — MCF-10A MECs respond to the dimensionality of the microenvironment. (A) The statistical difference between the distributions of protrusion widths comparing cells adhered to rBM-coated grids (2D; rBM^soft/rBM^2D condition) and cells encased with rBM (3D; rBM^3D condition) is highly significant (see Supplemental Table S1 for significance levels and p-values). (B, C) Slices 2 nm thick through representative tomograms of cells under rBM^2D, B, and rBM^3D, C, conditions. Scale bars are 200 nm. (D) The statistical difference between the relative percentages of filled intracellular membrane-enclosed compartments when cells under rBM^2D and rBM^3D conditions are compared is highly significant (see Supplemental Table S2 for significance levels and p-values). (E, F) Slices 2 nm thick through representative tomograms of cells under rBM^2D, E, and rBM^3D, F, conditions. Filled intracellular membrane-enclosed compartments are marked by yellow dots. Scale bars, 200 nm.