FIGURE 11:

Pharmacologic inhibition of Rac1 inhibits local and distant metastases in vivo. Gene expression levels of targeted luciferase qPCR analyses of omental and lung tissues isolated from mouse xenografts of SKOV3ip ovarian cancer cells. Samples are from mice treated with 5 mg/kg/d R-ketorolac or placebo for 4 wk. Data represented are mean ± SE. (A) Omental tissue data are from one experiment with five biological replicates. ** indicates p value < 0.01, where values represent relative expression for R-ketorolac compared with placebo (1.0) and normalized to 18s rRNA using unpaired two-tailed t test. (B) Lung tissue data are combined from one experiment with five biological replicates. *** indicates p value < 0.001, where values represent relative expression for R-ketorolac compared with placebo (1.0) and normalized to 18s rRNA using unpaired two-tailed t test.