Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 18;33(14):ar138. doi: 10.1091/mbc.E21-11-0540

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Rivera et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial-Share Alike 4.0 International Creative Commons License.

PMC Copyright notice

FIGURE 6: — NetLogo world set up for OCMetSim-Single Cells and OCMetSim-Spheroids and parameter validation. (A) Representative images of the NetLogo simulation space setup for OCMetSim-Single Cells and OCMetSim-Spheroids. Ovarian cancer cells/spheroids (yellow agents) move between the peritoneum (black patches), circulation (red patches), and to a distant metastatic niche (brown patches with white agents) based on Rac1 expression. Green patches represent the space ovarian cancer cells can adhere to the blood vessel using the parameters set from the ECIS/mesothelial clearance experiments. Blue patches represent the invaded cells into the blood vessel based on parameter set from the Matrigel invasion/mesothelial clearance experiments. The cyan patches represent adhesion to a distant metastatic niche, and the magenta patches represent invasion into a distant metastatic niche tissue. Simulations were run to compare the rate and number of invaded cells into a distant metastatic niche with Rac1 OE or KD. (B) The invasion parameters were validated running simulations with a Poisson distribution for rate of invasion using the Matrigel experimental data from Figure 3 as described in the Results and Materials and Methods sections. The simulations confirm that a Poisson distribution for rate of invasion produces results similar to those for the experimental data.