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. 2022 Nov 18;33(14):ar136. doi: 10.1091/mbc.E22-06-0205

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© 2022 Chumki et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 5: — The role of p115RhoGEF in TJ maintenance and local TJ remodeling. Model showing mechanism by which p115RhoGEF activates RhoA for TJ maintenance and local remodeling. Top: 3D view of epithelial cells. Bottom left: 3D view of cell–cell junctions showing that p115RhoGEF maintains baseline junctional RhoA activation to support the actomyosin array, TJs, and AJs. Bottom right: en face view of junction highlighted showing how p115RhoGEF recruitment and/or activation at sites of TJ damage activates Rho flares for local TJ repair and remodeling.