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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Pain. 2022 Apr 28;163(12):e1207–e1216. doi: 10.1097/j.pain.0000000000002667

Figure 1. A ketogenic diet prevents methylglyoxal-evoked mechanical allodynia.

Figure 1.

(A) Experimental design for assessing effects of a ketogenic diet on methylglyoxal (MGO) evoked nociception. Mice were provided chow or a ketogenic diet for one week before receiving a 25 μl intraperitoneal injection of 720 ng MGO. Sensory behavioral testing with Von Frey filaments was conducted for two weeks following injection prior to sacrifice. (B) Chow-fed mice receiving an injection of MGO quickly developed mechanical allodynia that persisted through the course of the experiment. Mice fed a ketogenic diet, however, never developed allodynia following MGO injection (n=8). Mixed-models ANOVA with repeated measures and Tukey’s post hoc test; *p < 0.05 compared to chow-fed saline-injected mice.