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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Pain. 2022 Apr 28;163(12):e1207–e1216. doi: 10.1097/j.pain.0000000000002667

Figure 3. Validation of a behavioral assay for methylglyoxal detoxification.

Figure 3.

(A-B) Quantification of the number of nociceptive events engaged in nociceptive behavior following intraplantar injection of MGO with, and without, aminoguanidine (n=8). Mice receiving intraplantar MGO injections exhibit increased number (A) and duration (B) of nocifensive behaviors, which is abrogated by pre-incubating MGO with aminoguanidine. (A-B) Three-way ANOVA and Tukey’s post hoc test; * p < 0.05 compared to chow-fed saline-injected, *p < 0.05 between two conditions.