Figure 3. MALAT1 knockdown reduces the proliferating ability of Müller glia.

• B
  Four‐month‐old male C57BL/6J mice received an intravitreous injection of scrambled (Scr) shRNA or MALAT1 (M) shRNA, or left untreated for 1 week. Then, ONT models were built, and BrdU (50 mg/kg) was injected at day 7 after building ONT model. At day 14 after building ONT model, these mice were killed and then stained with BrdU and glutamine synthetase (GS) to detect the proliferation ability of Müller glia. Data are presented as mean ± standard deviation (SD), n = 5 animals per group; scale bar, 100 μm; one‐way ANOVA followed by Dunnet's multiple comparison test; *P = 0.0002 (ONT + M vs. ONT); P = 0.8327 (ONT + Scr vs. ONT); *P = 0.0013 (ONT + M vs. ONT + Scr). The representative images of one replicate experiment and statistical results were shown.

Source data are available online for this figure.