Table 4.

Top statistically significant Gene Ontology molecular functions

Model	Molecular Function	Fold Enrichment
CD HCC vs. NASH	Hormone binding	3.05
	DNA-binding transcription activator activity, RNA polymerase II-specific	1.88
	RNA polymerase II cis-regulatory region sequence-specific DNA binding	1.72
	Calcium ion binding	1.57
CS HCC vs. NASH	Neuropeptide receptor activity	2.76
	Voltage-gated potassium channel activity	2.03
	DNA-binding transcription activator activity, RNA polymerase II-specific	1.61
	DNA binding transcription repressor activity, RNA polymerase-II specific	1.5
	RNA polymerase II cis-regulatory region sequence-specific DNA binding	1.49
	Signaling receptor activator activity	1.39

Top statistically significant Gene Ontology molecular functions revealed by enrichment analysis between HCC and NASH in the choline deficient and choline supplemented mice