Table 5.

Enriched molecular functions in hypomethylated regions between HCC and NASH

Model	Molecular Function	Fold Enrichment
CD HCC vs. NASH	DNA-binding transcription activator activity, RNA polymerase II-specific	2.14
	RNA polymerase II cis-regulatory region sequence-specific DNA binding	1.82
	Protein binding	1.17
CS HCC vs. NASH	Wnt-protein binding	4.20
	Frizzled binding	3.17
	DNA-binding transcription activator activity, RNA polymerase II-specific	2.21
	DNA-binding transcription repressor activity, RNA polymerase II-specific	2.07
	RNA polymerase II cis-regulatory region sequence-specific DNA binding	2.00
	Receptor ligand activity	1.52
	Cation binding	1.18

Top statistically significant Gene Ontology molecular functions revealed by enrichment analysis of hypomethylated regions between HCC and NASH in the choline deficient and choline supplemented mice