Table 3.

Prognostic factors of KPS and ADL impairment after reirradiation; univariate analysis

Variable	Hazard ratio [95% CI]	p-value
KPS
Male gender	0.88 [0.40; 1.98]	0.763
Initial brain surgery	1.20 [0.48; 3.03]	0.697
Motor deficiency	1.32 [0.45; 3.88]	0.615
Antiepileptic medication	0.71 [0.32; 1.59]	0.405
Headaches	2.44 [1.07; 5.59]	0.035
Age (years) > 60	1.0 [0.45; 2.24]	1
Steroids (mg)	1.47 [0.64; 3.38]	0.363
PTV (cc)*	1.57 [1.19; 2.08]	0.028
KPS (%) ≥ 90	1.51 [0.60; 3.81]	0.388
Time from RTCT to fSBReRT (months) < 12	1.36 [0.59; 3.10]	0.473
Number of recurrences before reirradiation ≥ 1	1.27 [0.50; 3.20]	0.617
Multifocality	1.66 [0.49; 5.62]	0.412
Brain topography
Cortical	1
Subcortical	2.54 [1.00;6.44]	0.050
ADL
Male gender	0.66 [0.24; 1.77]	0.410
Initial brain surgery	0.76 [0.26; 2.21]	0.617
Motor deficiency	2.99 [0.94; 9.54]	0.064
Antiepileptic medication	0.79 [0.29; 2.13]	0.650
Headaches	2.52 [0.91; 6.99]	0.075
Age (years) > 60	0.95 [0.35; 2.57]	0.924
Steroids (mg)	2.12 [0.78; 5.78]	0.141
PTV (cc)*	1.0 [1.0; 1.0]	0.481
KPS (%) ≥ 90	0.26 [0.09; 0.74]	0.011
Time from RTCT to fSBReRT (months) < 12	2.39 [0.77; 7.45]	0.131
Number of recurrences before reirradiation ≥ 1	1.36 [0.43; 4.30]	0.599
Multifocality	1.78 [0.36; 6.98]	0.583
Brain topography
Cortical	1
Subcortical	2.11 [0.68; 6.58]	0.196

CI, confidence interval; RTCT, concomitant adjuvant chemotherapy plus radiotherapy; fSRT, fractionated stereotactic RT

*HR computed for an increase of 10 cc