Table 4.
Prognosis factors for decreased PFS by univariate analysis
| Variable | Hazard ratio [95% CI] | p-value |
|---|---|---|
| Male gender | 0.85 [0.50; 1.47] | 0.566 |
| Initial brain surgery | 0.48 [0.27; 0.86] | 0.013 |
| Motor deficiency | 1.42 [0.68; 2.94] | 0.350 |
| Antiepileptic medication | 1.17 [0.69; 1.98] | 0.567 |
| Headaches | 0.86 [0.46; 1.61] | 0.645 |
| Age (years) > 60 | 0.67 [0.40; 1.13] | 0.135 |
| Steroids (mg) | 1.81 [1.04; 3.16] | 0.037 |
| PTV (cc) * | 1.14 [0.90; 1.44] | 0.269 |
| KPS (%) ≥ 90 | 1.01 [0.58; 1.73] | 0.985 |
| Time from RTCT to fSBReRT (months) < 12 | 0.60 [0.35; 1.01] | 0.055 |
| Number of recurrences before reirradiation ≥ 1 | 1.84 [0.98; 3.44] | 0.056 |
| Multifocality | 1.18 [0.47; 2.99] | 0.715 |
| Brain topography | ||
| Cortical | 1 | |
| Subcortical | 1.58 [0.77; 3.26] | 0.214 |
CI, confidence interval; RTCT, concomitant adjuvant chemotherapy plus radiotherapy; fSRT, fractionated stereotactic RT
*HR computed for an increase of 10 cc